abstract：PURPOSE:The purpose of our study was 1) to evaluate the diagnostic performance of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT), 2) to assess the impact of FDG PET/CT on treatment decision-making, and 3) to estimate the prognostic value of FDG PET/CT in the restaging process a...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Alongi P,Picchio M,Zattoni F,Spallino M,Gianolli L,Saladini G,Evangelista L

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate metabolic and textural parameters from pretreatment [(18)F]FDG PET/CT scans for the prediction of neoadjuvant radiation chemotherapy response and 3-year disease-free survival (DFS) in patients with locally advanced rectal cancer (LARC). METHODS:We performed a retrospect...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Bang JI,Ha S,Kang SB,Lee KW,Lee HS,Kim JS,Oh HK,Lee HY,Kim SE

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:Positron emission tomography (PET) radioligands specific to α7 nicotinic acetylcholine receptors (nAChRs) afford in vivo imaging of this receptor for neuropathologies such as Alzheimer's disease, schizophrenia, and substance abuse. This work aims to characterize the kinetic properties of an α7-nAChR-specific ra...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Hillmer AT,Zheng MQ,Li S,Scheunemann M,Lin SF,Holden D,Labaree D,Ropchan J,Teodoro R,Deuther-Conrad W,Carson RE,Brust P,Huang Y

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:Myocardial blood flow (MBF) measurement using positron emission tomography (PET) from the washout rate of (15)O-water is theoretically independent of tissue attenuation. The aim of this study was to evaluate the impact of not using attenuation correction in the assessment of coronary endothelial function and my...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Tuffier S,Legallois D,Belin A,Joubert M,Bailliez A,Redonnet M,Agostini D,Manrique A

更新日期：2016-02-01 00:00:00

abstract：:In Alzheimer's disease (AD), the deposition of β-amyloid (Aβ) is hypothesized to result in a series of secondary neurodegenerative processes, leading ultimately to synaptic dysfunction and neuronal loss. Since the advent of the first Aβ-specific positron emission tomography (PET) ligand, (11)C-Pittsburgh compound B ([...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Heurling K,Leuzy A,Zimmer ER,Lubberink M,Nordberg A

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:The washout rate (WR) has been used in (123)I-metaiodobenzylguanidine (MIBG) imaging to evaluate cardiac sympathetic innervation. However, WR varies depending on the time between the early and late MIBG scans. Late scans are performed at either 3 or 4 hours after injection of MIBG. The aim of this study was to ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Okuda K,Nakajima K,Sugino S,Kirihara Y,Matsuo S,Taki J,Hashimoto M,Kinuya S

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:Preclinical, or asymptomatic, Alzheimer's disease (AD) refers to the presence of positive AD biomarkers in the absence of cognitive deficits. This research concept is being applied to define target populations for clinical drug development. In a prospective community-recruited cohort of cognitively intact older...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Adamczuk K,Schaeverbeke J,Nelissen N,Neyens V,Vandenbulcke M,Goffin K,Lilja J,Hilven K,Dupont P,Van Laere K,Vandenberghe R

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:To evaluate the reproducibility of the combination of hybrid PET/MRI and the (68)Ga-PSMA-11 tracer in depicting lymph node (LN) and bone metastases of prostate cancer (PC) in comparison with that of PET/CT. MATERIALS AND METHODS:A retrospective analysis of 26 patients who were subjected to (68)Ga-PSMA PET/CTlo...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Freitag MT,Radtke JP,Hadaschik BA,Kopp-Schneider A,Eder M,Kopka K,Haberkorn U,Roethke M,Schlemmer HP,Afshar-Oromieh A

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:(131)Iodine (I131)-metaiodobenzylguanidine (mIBG) is a radionuclide-based treatment option for metastatic gastrointestinal-pancreatic neuroendocrine tumours (GEP NET). This study aimed at identifying prognostic indicators of long-term outcome based on initial evaluation following a first mIBG treatment (7400...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Mulholland N,Chakravartty R,Devlin L,Kalogianni E,Corcoran B,Vivian G

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:Radiolabelled somatostatin (SST) analogues have proven useful in diagnosing tumours positive for SST receptor (SSTR). As different subtypes of SSTR are expressed on the tumour cell surface, the choice of appropriate therapeutic SST analogue is crucial. We evaluated the SSTR status of thyroid cancer patients who...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Traub-Weidinger T,Putzer D,von Guggenberg E,Dobrozemsky G,Nilica B,Kendler D,Bale R,Virgolini IJ

更新日期：2015-12-01 00:00:00

abstract：INTRODUCTION:Mastocytosis is a clonal haematological disease characterized by uncontrolled proliferation and the activation of mast cells. The value of FDG-PET/CT (FDG-PET) in mastocytosis has yet to be determined. METHODS:We retrospectively identified patients with an established diagnosis of systemic mastocytosis (S...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Djelbani-Ahmed S,Chandesris MO,Mekinian A,Canioni D,Brouzes C,Hanssens K,Pop G,Durieu I,Durupt S,Grosbois B,Besnard S,Tournilhac O,Beyne-Rauzy O,Agapé P,Delmer A,Ranta D,Jeandel PY,Georgin-Lavialle S,Frenzel L,Damaj

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:We report the biodistribution and radiation dosimetry of an integrin αvβ3 specific PET tracer (18)F-AlF-NOTA-E[PEG4-c(RGDfk)]2) (denoted as (18)F-Alfatide II). We also assessed the value of (18)F-Alfatide II in patients with brain metastases. METHODS:A series of torso (from the skull to the thigh) static image...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Yu C,Pan D,Mi B,Xu Y,Lang L,Niu G,Yang M,Wan W,Chen X

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:Point-spread function (PSF) or PSF + time-of-flight (TOF) reconstruction may improve lesion detection in oncologic PET, but can alter quantitation resulting in variable standardized uptake values (SUVs) between different PET systems. This study aims to validate a proprietary software tool (EQ.PET) to harmonize ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Quak E,Le Roux PY,Hofman MS,Robin P,Bourhis D,Callahan J,Binns D,Desmonts C,Salaun PY,Hicks RJ,Aide N

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:To assess the value of SPECT/CT in patients with carpal boss (CB). METHODS:In 24 wrists with CB (18 right-sided, 6 left-sided) in 21 patients, planar images and SPECT/CT images were obtained. Three patients had bilateral CB. The grade of uptake (0 absent, 1 low, 2 moderate, 3 high) on planar imaging and SPECT/...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Bhure U,Hug U,Huellner MW,Grünig H,Zander A,Del Sol Pérez Lago M,Strobel K

更新日期：2015-11-01 00:00:00

abstract：PURPOSE:[(18)F]FPEB is a promising PET radioligand for the metabotropic glutamate receptor 5 (mGluR5), a potential target for the treatment of neuropsychiatric diseases. The purpose of this study was to evaluate the test-retest reproducibility of [(18)F]FPEB in the human brain. METHODS:Seven healthy male subjects were...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Park E,Sullivan JM,Planeta B,Gallezot JD,Lim K,Lin SF,Ropchan J,McCarthy TJ,Ding YS,Morris ED,Williams WA,Huang Y,Carson RE

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:Epicardial adipose tissue (EAT) has been linked to coronary artery disease (CAD) and coronary microvascular dysfunction. However, its injurious effect may also impact the underlying myocardium. This study aimed to determine the impact of obesity on the quantitative relationship between left ventricular mass (LV...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Bakkum MJ,Danad I,Romijn MA,Stuijfzand WJ,Leonora RM,Tulevski II,Somsen GA,Lammertsma AA,van Kuijk C,van Rossum AC,Raijmakers PG,Knaapen P

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:Here, the expression of F4/80 on the cell surface of murine macrophages was exploited to develop a novel imaging tracer that could visualize macrophages in vivo. METHODS:The immunoreactive fraction and IC50 of anti-F4/80-A3-1, conjugated with diethylenetriaminepentaacetic acid (DTPA) and radiolabelled with (11...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Terry SY,Boerman OC,Gerrits D,Franssen GM,Metselaar JM,Lehmann S,Oyen WJ,Gerdes CA,Abiraj K

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:The objective of this study was to determine the incremental staging information provided by positron emission tomography/computed tomography (PET/CT) and its impact on management plans in patients with untreated stage III-IV head and neck squamous cell carcinoma (HNSCC). METHODS:We prospectively studied, betw...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Cacicedo J,Fernandez I,Del Hoyo O,Dolado A,Gómez-Suarez J,Hortelano E,Sancho A,Pijoan JI,Alvarez J,Espinosa JM,Gaafar A,Bilbao P

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:In recent decades, the use of radiopharmaceuticals in the assessment of hepatocellular carcinoma (HCC) has become established, and new findings indicate that radiolabelled choline has considerable potential in this setting. Therefore, in this study we aimed to assess the diagnostic role of (11)C-choline positro...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Lopci E,Torzilli G,Poretti D,de Neto LJ,Donadon M,Rimassa L,Lanza E,Sabongi JG,Ceriani R,Personeni N,Palmisano A,Pedicini V,Comito T,Scorsetti M,Chiti A

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:Fusion dual-tracer SPECT imaging enables physiological rather than morphological voxel-based partitioning and dosimetry for (90)Y hepatic radioembolization (RE). We evaluated its prognostic value in a large heterogeneous cohort of patients with extensive hepatic malignancy. METHODS:A total of 122 patients with...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Lam MG,Banerjee A,Goris ML,Iagaru AH,Mittra ES,Louie JD,Sze DY

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:Increasing evidence supports the value of peptide receptor radionuclide therapy (PRRT) in patients with metastatic neuroendocrine tumours (NET), but there are limited data on its specific efficacy in NET of small intestinal (midgut) origin. This study aims to define the benefit of PRRT with (177)Lu-octreotate f...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Sabet A,Dautzenberg K,Haslerud T,Aouf A,Sabet A,Simon B,Mayer K,Biersack HJ,Ezziddin S

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:(11)C-methionine (MET) PET is an established diagnostic tool for glioma. Studies have suggested that MET uptake intensity in the tumor is a useful index for predicting patient outcome. Because MET uptake is known to reflect tumor expansion more accurately than MRI, we aimed to elucidate the association between ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kobayashi K,Hirata K,Yamaguchi S,Manabe O,Terasaka S,Kobayashi H,Shiga T,Hattori N,Tanaka S,Kuge Y,Tamaki N

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:The high failure rates in the radiotherapy (RT) target volume suggest that patients with locally advanced oesophageal cancer (LAOC) would benefit from increased total RT doses. High 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) uptake (hotspot) on pre-RT FDG positron emission tomography (PET)/CT has been reported to ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Calais J,Dubray B,Nkhali L,Thureau S,Lemarignier C,Modzelewski R,Gardin I,Di Fiore F,Michel P,Vera P

更新日期：2015-05-01 00:00:00

abstract：:In locally advanced head and neck squamous cell carcinoma (HNSCC), the role of imaging becomes more and more critical in the management process. In this framework, molecular imaging techniques such as PET allow noninvasive assessment of a range of tumour biomarkers such as metabolism, hypoxia and proliferation, which ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Differding S,Hanin FX,Grégoire V

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:Brain serotonin 6 receptor (5-HT6) is one of the most recently identified serotonin receptors. It is a potent therapeutic target for psychiatric and neurological diseases, e.g. schizophrenia and Alzheimer's disease. Since no specific fluorinated radioligand has yet been successfully used to study this receptor ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Becker G,Colomb J,Sgambato-Faure V,Tremblay L,Billard T,Zimmer L

更新日期：2015-03-01 00:00:00

abstract：PURPOSE:Salvage of young patients with follicular lymphoma (FL) after R-CHOP includes salvage immunochemotherapy followed by autologous stem cell transplantation (ASCT). Previous studies dealing with relapsed Hodgkin lymphoma have shown the prognostic value of PET/CT prior to ASCT. METHODS:We retrospectively analysed ...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Alcantara M,Dupuis J,Mareschal S,Julian A,Cottereau AS,Becker S,Dubois S,Oberic L,Huynh A,Meignan M,Laurent G,Tilly H,Haioun C,Ysebaert L

更新日期：2015-02-01 00:00:00

abstract：PURPOSE:To evaluate the diagnostic potential of PET/MRI with [(18)F]FDG in recurrent ovarian and cervical cancer in comparison to PET/CT. METHODS:A group of 19 patients with suspected recurrence of pelvic malignancies (ovarian cancer, 11 patients; cervical cancer, 8 patients) scheduled for an [(18)F]FDG PET/CT were su...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Beiderwellen K,Grueneisen J,Ruhlmann V,Buderath P,Aktas B,Heusch P,Kraff O,Forsting M,Lauenstein TC,Umutlu L

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:To assess the diagnostic performance of PET/MR in patients with non-small-cell lung cancer. METHODS:Fifty consecutive consenting patients who underwent routine (18)F-FDG PET/CT for potentially radically treatable lung cancer following a staging CT scan were recruited for PET/MR imaging on the same day. Two exp...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Fraioli F,Screaton NJ,Janes SM,Win T,Menezes L,Kayani I,Syed R,Zaccagna F,O'Meara C,Barnes A,Bomanji JB,Punwani S,Groves AM

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to compare the accuracy of (123)I-MIBG SPECT/CT with that of (68)Ga-DOTATOC PET/CT for staging extraadrenal paragangliomas (PGL) using both functional and anatomical images (i.e. combined cross-sectional imaging) as the reference standards. METHODS:The study included three men and sev...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Kroiss A,Shulkin BL,Uprimny C,Frech A,Gasser RW,Url C,Gautsch K,Madleitner R,Nilica B,Sprinzl GM,Gastl G,Fraedrich G,Virgolini IJ

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to develop a methodology for the comparison of pathology specimens after prostatectomy (post-S) with PET images obtained before surgery (pre-S). This method was used to evaluate the merit of (11)C-choline PET/CT for delineation of gross tumour volume (GTV) in prostate cancer (PC). MET...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Grosu AL,Weirich G,Wendl C,Prokic V,Kirste S,Geinitz H,Souvatzoglou M,Gschwend JE,Schwaiger M,Molls M,Weber WA,Treiber U,Krause BJ

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:Various strategies have been applied to increase the engraftment of an intramyocardial cell transplant (Tx) to treat ischemic myocardium. Thereby, co-transplanted fibroblasts (FB) improve the long-term survival of stem cell derivatives (SCD) in a murine model of myocardial infarction. For therapeutic use, the t...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Lang C,Lehner S,Todica A,Boening G,Zacherl M,Franz WM,Krause BJ,Bartenstein P,Hacker M,David R

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:The aim of this retrospective two-centre study was to investigate the clinical impact of (11)C-choline PET/CT on treatment management decisions in patients with recurrent prostate cancer (rPCa) after radical therapy. METHODS:Enrolled in this retrospective study were 150 patients (95 from Bologna, 55 from Würzb...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Ceci F,Herrmann K,Castellucci P,Graziani T,Bluemel C,Schiavina R,Vollmer C,Droll S,Brunocilla E,Mazzarotto R,Buck AK,Fanti S

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:Aortic metabolic activity is suggested to correlate with presence and progression of aneurysmal disease, but has been inadequately studied. This study investigates the 2-[(18)F] fluoro-2-deoxy-D-glucose ((18)F-FDG) uptake in a population of infra-renal abdominal aortic aneurysms (AAA), compared to a matched non...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Barwick TD,Lyons OT,Mikhaeel NG,Waltham M,O'Doherty MJ

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:The Alzheimer's disease (AD) pathology is characterized by fibrillar amyloid deposits and neurofibrillary tangles, as well as the activation of astrocytosis, microglia activation, atrophy, dysfunctional synapse, and cognitive impairments. The aim of this study was to test the hypothesis that astrocytosis is cor...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Choo IL,Carter SF,Schöll ML,Nordberg A

更新日期：2014-11-01 00:00:00

abstract：UNLABELLED:There are specific dose recommendations for diagnostic amyloid PET imaging with 18F-florbetapir, but they may not apply to research studies using regional quantitative analysis. We, therefore, studied the effect of tracer dose reduction on the discriminative power of regional analysis. METHODS:Using bootstr...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Herholz K,Evans R,Anton-Rodriguez J,Hinz R,Matthews JC

更新日期：2014-11-01 00:00:00

abstract：PURPOSE:[(18)F]Fluoro-3'-deoxy-3'-L-fluorothymidine ([(18)F]FLT) is a tissue proliferation marker which has been widely validated as a tumour-specific imaging tracer for PET. [(18)F]FLT uptake in breast cancer is generally quantified at the region level or through first-order statistical descriptors (mean or maximum va...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Veronese M,Rizzo G,Aboagye EO,Bertoldo A

更新日期：2014-09-01 00:00:00

abstract：PURPOSE:Our aim was to investigate the association between (18)F-fluorodeoxyglucose (FDG) uptake and event-free survival in patients in whom a differentiated thyroid cancer (DTC) was detected by (18)F-FDG positron emission tomography (PET)/CT. METHODS:Among 884 focal (18)F-FDG PET thyroid incidentalomas referred to ou...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Piccardo A,Puntoni M,Bertagna F,Treglia G,Foppiani L,Arecco F,Giubbini R,Naseri M,Cistaro A,Cabria M,Bardesono F,Ceriani L,Orlandi F,Giovanella L

更新日期：2014-08-01 00:00:00

abstract：PURPOSE:To explore the potential complementary value of PET/CT and dynamic contrast-enhanced MRI in predicting pathological response to neoadjuvant chemotherapy (NAC) of breast cancer and the dependency on breast cancer subtype. METHODS:We performed (18)F-FDG PET/CT and MRI examinations before and during NAC. The imag...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Pengel KE,Koolen BB,Loo CE,Vogel WV,Wesseling J,Lips EH,Rutgers EJ,Valdés Olmos RA,Vrancken Peeters MJ,Rodenhuis S,Gilhuijs KG

更新日期：2014-08-01 00:00:00

abstract：PURPOSE:Pretargeted radioimmunotherapy (PRIT) with bispecific antibodies (bsMAb) and a radiolabeled peptide reduces the radiation dose to normal tissues. Here we report the accuracy of an (111)In-labeled pretherapy test dose for personalized dosing of (177)Lu-labeled IMP288 following pretargeting with the anti-CEA × an...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Schoffelen R,Woliner-van der Weg W,Visser EP,Goldenberg DM,Sharkey RM,McBride WJ,Chang CH,Rossi EA,van der Graaf WT,Oyen WJ,Boerman OC

更新日期：2014-08-01 00:00:00

abstract：PURPOSE:PET is a powerful tool for assessing targeted therapy. Since (18)F-FDG shows a potential prognostic value in medullary thyroid carcinoma (MTC), this study evaluated (18)F-FDG PET alone and combined with morphological and biomarker evaluations as a surrogate marker of overall survival (OS) in patients with progr...

journal_title：European journal of nuclear medicine and molecular imaging

authors： Salaun PY,Campion L,Ansquer C,Frampas E,Mathieu C,Robin P,Bournaud C,Vuillez JP,Taieb D,Rousseau C,Drui D,Mirallié E,Borson-Chazot F,Goldenberg DM,Chatal JF,Barbet J,Kraeber-Bodéré F

更新日期：2014-08-01 00:00:00